Scientists from Harvard have developed a technology to create a working biomodel of the left ventricle of the human heart. It behaves like a real organ, which allows you to conduct experiments and operations on the site without risking the life of the carrier. In the future, it is worth creating a full-sized heart.
Cardiac tissue is obtained by growing living cells on a nanofibrous basis. Scientists took the fibers of biodegradable gelatin and polyester, formed from them a frame in the form of a sac, with a cellular surface, on which the induced stem cells were planted. After several days of intensive growth, the cells formed a thin layer of cardiac tissue, the stem self-destructed, and the experimenters forced the formed model of the ventricle to fight.
When stimulating with isoproterenol, the rate of contractions increased, with physical damage to the tissues, signs of a heart attack were observed. The model reacted so remarkably to external stimuli that scientists managed to build a bioreactor for it, in which the artificial part of the heart normally lived for more than six months. The facility is equipped with locks through which the experimenters carried out various manipulations – from infecting the model with pathogenic microbes to installing artificial valves.
The authors of the development are delighted with the results, because now it is possible to take samples of the tissues of the most important organ from the patient, to grow a copy of it and to work on it any radical methods of treatment without risk for the person himself. More precisely, such opportunities will open in the near future, as well as the opportunity to grow a new body from the stored samples instead of the lost one.